In the late 1980s she moved to Spain to pursue a career in modelling. Her first television appearance was in the drama series Dark Justice. She moved to Los Angeles, California with the series in 1992. Her big breakthrough came when she was chosen to play the leather-clad hacker Trinity in the 1999 box office success The Matrix. She reprised the role of Trinity in two sequels as well as providing voice-overs for video game and animated spin-offs of the film. She also appeared as Natalie in the critically-acclaimed Memento in 2000 as well as in a supporting role with Juliette Binoche in the Academy Award nominated film, Chocolat starring Johnny Depp.
She has also appeared in the Matrix sequels and a few other feature films since her success in the Matrix trilogy.