In 2000, Carrey re-teamed with the Farrelly Brothers (who had directed him in Dumb & Dumber) in their comedy, Me, Myself and Irene, about a state trooper with multiple personalities who romances a woman played by Renée Zellweger. The film grossed $24 million dollars on its opening weekend and $90 million by the end of its domestic run. Carrey has since continued to appear in successful comedies as well as more dramatic roles. His performance in Eternal Sunshine of the Spotless Mind (2004) earned high praise from critics, who once again incorrectly predicted that Carrey would receive an Oscar nomination, although the film won an Academy Award for Best Original Screenplay, and co-star Kate Winslet received a nomination for her performance. (Again, Carrey was nominated for a Golden Globe for this performance, his sixth.)
In 2003, Carrey re-teamed with Tom Shadyac for the financially successful comedy Bruce Almighty. Earning over $242 million in the U.S. and over $484 million worldwide, this film became the second highest grossing live-action comedy of all time.